KEGG   ENZYME: 1.14.12.16Help
Entry
EC 1.14.12.16               Enzyme                                 

Name
2-hydroxyquinoline 5,6-dioxygenase;
2-oxo-1,2-dihydroquinoline 5,6-dioxygenase;
quinolin-2-ol 5,6-dioxygenase;
quinolin-2(1H)-one 5,6-dioxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
BRITE hierarchy
Sysname
quinolin-2-ol,NADH:oxygen oxidoreductase (5,6-hydroxylating)
Reaction(IUBMB)
quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+ [RN:R05157]
Reaction(KEGG)
Substrate
quinolin-2-ol [CPD:C06338];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
2,5,6-trihydroxy-5,6-dihydroquinoline [CPD:C06339];
NAD+ [CPD:C00003]
Comment
3-Methylquinolin-2-ol, quinolin-8-ol and quinolin-2,8-diol are also substrates. Quinolin-2-ols exist largely as their quinolin-2(1H)-one tautomers
History
EC 1.14.12.16 created 1999
Reference
1  [PMID:7556204]
  Authors
Schach S, Tshisuaka B, Fetzner S, Lingens F.
  Title
Quinoline 2-oxidoreductase and 2-oxo-1,2-dihydroquinoline 5,6-dioxygenase from Comamonas testosteroni 63. The first two enzymes in quinoline and 3-methylquinoline degradation.
  Journal
Eur. J. Biochem. 232 (1995) 536-44.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
172399-50-7

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