KEGG   ENZYME: 1.14.12.19Help
Entry
EC 1.14.12.19               Enzyme                                 

Name
3-phenylpropanoate dioxygenase;
HcaA1A2CD;
Hca dioxygenase;
3-phenylpropionate dioxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
BRITE hierarchy
Sysname
3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating)
Reaction(IUBMB)
(1) 3-phenylpropanoate + NADH + H+ + O2 = 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+ [RN:R06782];
(2) (2E)-3-phenylprop-2-enoate + NADH + H+ + O2 = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NAD+
Reaction(KEGG)
R06782;
(other) R06783
Show
Substrate
3-phenylpropanoate;
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007];
(2E)-3-phenylprop-2-enoate [CPD:C00423]
Product
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate [CPD:C11588];
NAD+ [CPD:C00003];
(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate [CPD:C12623]
Comment
This enzyme catalyses a step in the pathway of phenylpropanoid compounds degradation. It catalyses the insertion of both atoms of molecular oxygen into positions 2 and 3 of the phenyl ring of 3-phenylpropanoate or (2E)-3-phenylprop-2-enoate.
History
EC 1.14.12.19 created 2005, modified 2011
Pathway
Phenylalanine metabolism
Microbial metabolism in diverse environments
Orthology
K05708  
3-phenylpropionate/trans-cinnamate dioxygenase subunit alpha
K05709  
3-phenylpropionate/trans-cinnamate dioxygenase subunit beta
Genes
ECO: 
b2538(hcaE) b2539(hcaF)
ECJ: 
JW2522(hcaE) JW2523(hcaF)
ECD: 
EBW: 
BWG_2302(hcaE) BWG_2303(hcaF)
ECOK: 
ECE: 
Z3809(hcaA1) Z3810(hcaA2)
ECS: 
ECF: 
ETW: 
ECSP_3482(hcaE) ECSP_3483(hcaF)
ELX: 
EOJ: 
EOI: 
EOH: 
EOK: 
ELR: 
ECX: 
ECW: 
ECM: 
ECY: 
ECR: 
ECK: 
ECT: 
EOC: 
CE10_2970(hcaE) CE10_2971(hcaF)
EUM: 
ELO: 
ELH: 
ESO: 
ESM: 
ESL: 
ECL: 
EBR: 
ECB_02430(hcaE) ECB_02431(hcaF)
EBD: 
EKO: 
EKF: 
EDH: 
EDJ: 
EUN: 
ELW: 
ECW_m2764(hcaE) ECW_m2765(hcaF)
ELL: 
WFL_13535(hcaE) WFL_13540(hcaF)
ELP: 
EBL: 
ECD_02430(hcaE) ECD_02431(hcaF)
EBE: 
B21_02394(hcaE) B21_02395(hcaF)
ECOA: 
ECOL: 
ECOO: 
ECOH: 
SFL: 
SF2585(hcaA1) SF2586(hcaA2)
SFX: 
S2757(hcaA1) S2758(hcaA2)
SFV: 
SFV_2586(hcaA1) SFV_2587(hcaA2)
SFE: 
SFxv_2841(hcaE) SFxv_2842(hcaF)
SFN: 
SFS: 
SFT: 
NCTC1_02841(hcaA1) NCTC1_02842(hcaA2)
SSN: 
SSON_2620(hcaA1) SSON_2621(hcaA2)
SSJ: 
SBO: 
SBO_2562(hcaA1) SBO_2563(hcaA2)
PLU: 
plu2204(hcaE) plu2205(hcaF)
PAY: 
PAU_02356(hcaF) PAU_02357(hcaE)
PTT: 
KPV: 
CFD: 
CIF: 
SFW: 
EBF: 
VEJ: 
VFU: 
AEI: 
CYQ: 
CZA: 
BCEN: 
BPLA: 
AFA: 
DEL: 
RBU: 
NAR: 
NPP: 
SPHP: 
SWI: 
AAY: 
WYH_01869(hcaE)
PNP: 
MSA: 
MVA: 
MAB: 
MAY: 
MABO: 
MAZ: 
MFT: 
CDR: 
CAZ: 
CII: 
CMV: 
NNO: 
REB: 
REQ: 
RAV: 
GOR: 
SCB: 
SCAB_2191(hcaE)
MIO: 
FRI: 
TRO: 
SAI: 
SACR: 
SACS: 
SIS: 
SIA: 
SIM: 
SID: 
SIY: 
SII: 
SIH: 
 » show all
Taxonomy
Reference
1  [PMID:9603882]
  Authors
Diaz E, Ferrandez A, Garcia JL.
  Title
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
  Journal
J. Bacteriol. 180 (1998) 2915-23.
  Sequence
[eco:b2538 b2539]
Reference
2  [PMID:6345502]
  Authors
Burlingame R, Chapman PJ.
  Title
Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli.
  Journal
J. Bacteriol. 155 (1983) 113-21.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system