KEGG   ENZYME: 1.14.12.4Help
Entry
EC 1.14.12.4                Enzyme                                 

Name
3-hydroxy-2-methylpyridinecarboxylate dioxygenase;
methylhydroxypyridinecarboxylate oxidase;
2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase;
methylhydroxypyridine carboxylate dioxygenase;
3-hydroxy-3-methylpyridinecarboxylate dioxygenase [incorrect];
3-hydroxy-2-methylpyridine-5-carboxylate,NAD(P)H:oxygen oxidoreductase (decyclizing)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
BRITE hierarchy
Sysname
3-hydroxy-2-methylpyridine-5-carboxylate,NAD(P)H:oxygen oxidoreductase (ring-opening)
Reaction(IUBMB)
3-hydroxy-2-methylpyridine-5-carboxylate + NAD(P)H + H+ + O2 = 2-(acetamidomethylene)succinate + NAD(P)+ [RN:R03385 R03386]
Reaction(KEGG)
Substrate
3-hydroxy-2-methylpyridine-5-carboxylate [CPD:C01270];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
2-(acetamidomethylene)succinate [CPD:C01215];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Comment
A flavoprotein (FAD).
History
EC 1.14.12.4 created 1972
Pathway
Vitamin B6 metabolism
Microbial metabolism in diverse environments
Orthology
K18071  
2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase
Genes
MLO: 
MAM: 
Taxonomy
Reference
1  [PMID:4306031]
  Authors
Sparrow LG, Ho PP, Sundaram TK, Zach D, Nyns EJ, Snell EE.
  Title
The bacterial oxidation of vitamin B6. VII. Purification, properties, and mechanism of action of an oxygenase which cleaves the 3-hydroxypyridine ring.
  Journal
J. Biol. Chem. 244 (1969) 2590-600.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
37256-69-2

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