KEGG   ENZYME: 1.14.12.5Help
Entry
EC 1.14.12.5                Enzyme                                 

Name
5-pyridoxate dioxygenase;
5-pyridoxate oxidase;
5-pyridoxate,NADPH:oxygen oxidoreductase (decyclizing)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
BRITE hierarchy
Sysname
5-pyridoxate,NADPH:oxygen oxidoreductase (ring-opening)
Reaction(IUBMB)
3-hydroxy-4-hydroxymethyl-2-methylpyridine-5-carboxylate + NADPH + H+ + O2 = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP+ [RN:R04570]
Reaction(KEGG)
Substrate
3-hydroxy-4-hydroxymethyl-2-methylpyridine-5-carboxylate [CPD:C04773];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
2-(acetamidomethylene)-3-(hydroxymethyl)succinate [CPD:C04690];
NADP+ [CPD:C00006]
Comment
A flavoprotein.
History
EC 1.14.12.5 created 1972
Pathway
Vitamin B6 metabolism
Reference
1  [PMID:4306031]
  Authors
Sparrow LG, Ho PP, Sundaram TK, Zach D, Nyns EJ, Snell EE.
  Title
The bacterial oxidation of vitamin B6. VII. Purification, properties, and mechanism of action of an oxygenase which cleaves the 3-hydroxypyridine ring.
  Journal
J. Biol. Chem. 244 (1969) 2590-600.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
37256-70-5

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