KEGG   ENZYME: 1.14.12.7Help
Entry
EC 1.14.12.7                Enzyme                                 

Name
phthalate 4,5-dioxygenase;
PDO ;
phthalate dioxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
BRITE hierarchy
Sysname
phthalate,NADH:oxygen oxidoreductase (4,5-hydroxylating)
Reaction(IUBMB)
phthalate + NADH + H+ + O2 = cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ [RN:R03630]
Reaction(KEGG)
Substrate
phthalate [CPD:C01606];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate [CPD:C04783];
NAD+ [CPD:C00003]
Comment
A system, containing a reductase which is an iron-sulfur flavoprotein (FMN), an iron-sulfur oxygenase, and no independent ferredoxin. Requires Fe2+.
History
EC 1.14.12.7 created 1990
Pathway
Polycyclic aromatic hydrocarbon degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K18068  
phthalate 4,5-dioxygenase
Genes
HAM: 
RPF: 
CNC: 
BVI: 
BMU: 
BMK: 
BYI: 
BUO: 
BUE: 
BPT: 
BHZ: 
POL: 
PNA: 
VEI: 
DEL: 
CTT: 
CTES: 
CID: 
 » show all
Taxonomy
Reference
1  [PMID:3805038]
  Authors
Batie CJ, LaHaie E, Ballou DP.
  Title
Purification and characterization of phthalate oxygenase and phthalate oxygenase reductase from Pseudomonas cepacia.
  Journal
J. Biol. Chem. 262 (1987) 1510-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
63626-44-8

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