KEGG   ENZYME: 1.14.12.9Help
Entry
EC 1.14.12.9                Enzyme                                 

Name
4-chlorophenylacetate 3,4-dioxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
BRITE hierarchy
Sysname
4-chlorophenylacetate,NADH:oxygen oxidoreductase (3,4-hydroxylating, dechlorinating)
Reaction(IUBMB)
4-chlorophenylacetate + NADH + H+ + O2 = 3,4-dihydroxyphenylacetate + chloride + NAD+ [RN:R03306]
Reaction(KEGG)
Substrate
4-chlorophenylacetate [CPD:C03077];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
3,4-dihydroxyphenylacetate [CPD:C01161];
chloride [CPD:C00698];
NAD+ [CPD:C00003]
Comment
A system, containing a reductase and an iron-sulfur oxygenase, and no independent ferredoxin. Requires Fe2+. Also acts on 4-bromophenyl acetate.
History
EC 1.14.12.9 created 1989 as EC 1.13.99.4, transferred 1992 to EC 1.14.12.9
Pathway
Tyrosine metabolism
Microbial metabolism in diverse environments
Reference
1  [PMID:3745216]
  Authors
Markus A, Krekel D, Lingens F.
  Title
Purification and some properties of component A of the 4-chlorophenylacetate 3,4-dioxygenase from Pseudomonas species strain CBS.
  Journal
J. Biol. Chem. 261 (1986) 12883-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
105006-00-6

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