KEGG   ENZYME: 1.14.13.10Help
Entry
EC 1.14.13.10               Enzyme                                 

Name
2,6-dihydroxypyridine 3-monooxygenase;
2,6-dihydroxypyridine oxidase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
2,6-dihydroxypyridine,NADH:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
2,6-dihydroxypyridine + NADH + H+ + O2 = 2,3,6-trihydroxypyridine + NAD+ + H2O [RN:R04130]
Reaction(KEGG)
Substrate
2,6-dihydroxypyridine [CPD:C03056];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
2,3,6-trihydroxypyridine [CPD:C03458];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
A flavoprotein.
History
EC 1.14.13.10 created 1976
Pathway
Nicotinate and nicotinamide metabolism
Microbial metabolism in diverse environments
Orthology
K19189  
2,6-dihydroxypyridine 3-monooxygenase
Genes
MSM: 
MSG: 
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MSH: 
MSA: 
MCB: 
MNE: 
MYV: 
MFT: 
ROP: 
ROA: 
SBH: 
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 » show all
Taxonomy
Reference
1  [PMID:4344227]
  Authors
Holmes PE, Rittenberg SC.
  Title
The bacterial oxidation of nicotine. VII. Partial purification and properties of 2,6-dihydroxypyridine oxidase.
  Journal
J. Biol. Chem. 247 (1972) 7622-7.
Reference
2  [PMID:4636328]
  Authors
Holmes PE, Rittenberg SC, Knackmuss HJ.
  Title
The bacterial oxidation of nicotine. 8. Synthesis of 2,3,6-trihydroxypyridine and accumulation and partial characterization of the product of 2,6-dihydroxypyridine oxidation.
  Journal
J. Biol. Chem. 247 (1972) 7628-33.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
39279-38-4

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