KEGG   ENZYME: 1.14.13.110Help
Entry
EC 1.14.13.110              Enzyme                                 

Name
geranylgeraniol 18-hydroxylase;
GGOH-18-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
geranylgeraniol,NADPH:oxygen oxidoreductase (18-hydroxylating)
Reaction(IUBMB)
geranylgeraniol + NADPH + H+ + O2 = 18-hydroxygeranylgeraniol + NADP+ + H2O [RN:R09122]
Reaction(KEGG)
Substrate
geranylgeraniol [CPD:C09094];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
18-hydroxygeranylgeraniol [CPD:C13273];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450).
History
EC 1.14.13.110 created 2009
Pathway
Diterpenoid biosynthesis
Biosynthesis of secondary metabolites
Reference
1
  Authors
Tansakul, P. and De-Eknamkul, W.
  Title
Geranylgeraniol-18-hydroxylase: the last enzyme in the plaunotol biosynthetic pathway in Croton sublyratus.
  Journal
Phytochemistry 47 (1998) 1241-1246.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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