KEGG   ENZYME: 1.14.13.115Help
Entry
EC 1.14.13.115              Enzyme                                 

Name
angelicin synthase;
CYP71AJ4 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
(+)-columbianetin,NADPH:oxygen oxidoreductase
Reaction(IUBMB)
(+)-columbianetin + NADPH + H+ + O2 = angelicin + NADP+ + acetone + 2 H2O [RN:R09002]
Reaction(KEGG)
Substrate
(+)-columbianetin [CPD:C19707];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
angelicin [CPD:C09060];
NADP+ [CPD:C00006];
acetone [CPD:C00207];
H2O [CPD:C00001]
Comment
This P-450 monooxygenase enzyme is involved in the formation of angular furanocoumarins. Attacks its substrate by syn-elimination of hydrogen from C-3'.
History
EC 1.14.13.115 created 2010
Reference
1  [PMID:19098286]
  Authors
Larbat R, Hehn A, Hans J, Schneider S, Jugde H, Schneider B, Matern U, Bourgaud F.
  Title
Isolation and functional characterization of CYP71AJ4 encoding for the first P450 monooxygenase of angular furanocoumarin biosynthesis.
  Journal
J. Biol. Chem. 284 (2009) 4776-85.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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