KEGG   ENZYME: 1.14.13.12Help
Entry
EC 1.14.13.12               Enzyme                                 

Name
benzoate 4-monooxygenase;
benzoic acid 4-hydroxylase;
benzoate 4-hydroxylase;
benzoic 4-hydroxylase;
benzoate-p-hydroxylase;
p-hydroxybenzoate hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
benzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)
Reaction(IUBMB)
benzoate + NADPH + H+ + O2 = 4-hydroxybenzoate + NADP+ + H2O [RN:R01295]
Reaction(KEGG)
Substrate
benzoate [CPD:C00180];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
4-hydroxybenzoate [CPD:C00156];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
Requires Fe2+ and tetrahydropteridine.
History
EC 1.14.13.12 created 1976
Pathway
ec00362  Benzoate degradation
ec00627  Aminobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K07824  benzoate 4-monooxygenase
Genes
NCR: NCU01086
NTE: NEUTE1DRAFT98143(NEUTE1DRAFT_98143)
SMP: SMAC_03160
PAN: PODANSg8616
TTT: THITE_2107910
MTM: MYCTH_2301715
CTHR: CTHT_0069080
MGR: MGG_13928
FGR: FGSG_00012 FGSG_08079 FGSG_10451 FGSG_13445
FPU: FPSE_07525 FPSE_07532 FPSE_10672
MAW: MAC_01732
CMT: CCM_08604
MBE: MBM_02231
ANG: ANI_1_418084(An09g03500)
PBL: PAAG_11325(PAAG_01629)
PTE: PTT_11926
ZTR: MYCGRDRAFT_53213(CYP-69)
ABP: AGABI1DRAFT115220(AGABI1DRAFT_115220) AGABI1DRAFT115340(AGABI1DRAFT_115340)
ABV: AGABI2DRAFT194181(AGABI2DRAFT_194181) AGABI2DRAFT194303(AGABI2DRAFT_194303)
 » show all
Taxonomy
Reference
1  [PMID:236777]
  Authors
Reddy CC, Vaidyanathan CS.
  Title
Purification, properties and induction of a specific benzoate-4-hydroxylase from Aspergillus niger (UBC 814).
  Journal
Biochim. Biophys. Acta. 384 (1975) 46-57.
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.12
IUBMB Enzyme Nomenclature: 1.14.13.12
ExPASy - ENZYME nomenclature database: 1.14.13.12
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.12
BRENDA, the Enzyme Database: 1.14.13.12
CAS: 39391-25-8

DBGET integrated database retrieval system