KEGG   ENZYME: 1.14.13.12Help
Entry
EC 1.14.13.12               Enzyme                                 

Name
benzoate 4-monooxygenase;
benzoic acid 4-hydroxylase;
benzoate 4-hydroxylase;
benzoic 4-hydroxylase;
benzoate-p-hydroxylase;
p-hydroxybenzoate hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
benzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)
Reaction(IUBMB)
benzoate + NADPH + H+ + O2 = 4-hydroxybenzoate + NADP+ + H2O [RN:R01295]
Reaction(KEGG)
Substrate
benzoate [CPD:C00180];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
4-hydroxybenzoate [CPD:C00156];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
Requires Fe2+ and tetrahydropteridine.
History
EC 1.14.13.12 created 1976
Pathway
Benzoate degradation
Aminobenzoate degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K07824  
benzoate 4-monooxygenase
Genes
NCR: 
NTE: 
NEUTE1DRAFT98143(NEUTE1DRAFT_98143)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
FGR: 
FPU: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
VDA: 
ELA: 
SSL: 
BFU: 
MBE: 
AFM: 
AOR: 
AOR_1_532194(AO090012000307)
ANG: 
ANI_1_418084(An09g03500)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
PAAG_11325(PAAG_01629)
URE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
PPL: 
DSQ: 
PCO: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT115220(AGABI1DRAFT_115220) AGABI1DRAFT115340(AGABI1DRAFT_115340)
ABV: 
AGABI2DRAFT194181(AGABI2DRAFT_194181) AGABI2DRAFT194303(AGABI2DRAFT_194303)
CPUT: 
SLA: 
UMA: 
PFP: 
PGR: 
MLR: 
BUR: 
 » show all
Taxonomy
Reference
1  [PMID:236777]
  Authors
Reddy CC, Vaidyanathan CS.
  Title
Purification, properties and induction of a specific benzoate-4-hydroxylase from Aspergillus niger (UBC 814).
  Journal
Biochim. Biophys. Acta. 384 (1975) 46-57.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
39391-25-8

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