KEGG   ENZYME: 1.14.13.137Help
Entry
EC 1.14.13.137              Enzyme                                 

Name
indole-2-monooxygenase;
BX2 (gene name);
CYP71C4 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
indole,NAD(P)H:oxygen oxidoreductase (2-hydroxylating)
Reaction(IUBMB)
indole + NAD(P)H + H+ + O2 = indolin-2-one + NAD(P)+ + H2O [RN:R07403]
Reaction(KEGG)
Substrate
indole [CPD:C00463];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
indolin-2-one [CPD:C12312];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses). It is a member of the cytochrome P-450 dependent monooxygenases.
History
EC 1.14.13.137 created 2012
Pathway
Benzoxazinoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K13223  
indole-2-monooxygenase
Genes
ZMA: 
Taxonomy
Reference
1  [PMID:9235894]
  Authors
Frey M, Chomet P, Glawischnig E, Stettner C, Grun S, Winklmair A, Eisenreich W, Bacher A, Meeley RB, Briggs SP, Simcox K, Gierl A.
  Title
Analysis of a chemical plant defense mechanism in grasses.
  Journal
Science. 277 (1997) 696-9.
  Sequence
Reference
2  [PMID:10385992]
  Authors
Glawischnig E, Grun S, Frey M, Gierl A.
  Title
Cytochrome P450 monooxygenases of DIBOA biosynthesis: specificity and conservation among grasses.
  Journal
Phytochemistry. 50 (1999) 925-30.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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