KEGG   ENZYME: 1.14.13.14Help
Entry
EC 1.14.13.14               Enzyme                                 

Name
trans-cinnamate 2-monooxygenase;
cinnamic acid 2-hydroxylase;
cinnamate 2-monooxygenase;
cinnamic 2-hydroxylase;
cinnamate 2-hydroxylase;
trans-cinnamic acid 2-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
trans-cinnamate,NADPH:oxygen oxidoreductase (2-hydroxylating)
Reaction(IUBMB)
trans-cinnamate + NADPH + H+ + O2 = 2-hydroxycinnamate + NADP+ + H2O [RN:R02254]
Reaction(KEGG)
Substrate
trans-cinnamate [CPD:C00423];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
2-hydroxycinnamate [CPD:C01772];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
History
EC 1.14.13.14 created 1976
Pathway
Phenylalanine metabolism
Phenylpropanoid biosynthesis
Biosynthesis of secondary metabolites
Microbial metabolism in diverse environments
Reference
1  [PMID:4153528]
  Authors
Gestetner B, Conn EE.
  Title
The 2-hydroxylation of trans-cinnamic acid by chloroplasts from Melilotus alba Desr.
  Journal
Arch. Biochem. Biophys. 163 (1974) 617-24.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
53126-56-0

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