KEGG   ENZYME: 1.14.13.145Help
Entry
EC 1.14.13.145              Enzyme                                 

Name
ent-cassa-12,15-diene 11-hydroxylase;
ent-cassadiene C11alpha-hydroxylase;
CYP76M7
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
ent-cassa-12,15-diene,NADPH:oxygen 11-oxidoreductase
Reaction(IUBMB)
ent-cassa-12,15-diene + O2 + NADPH + H+ = ent-11beta-hydroxycassa-12,15-diene + NADP+ + H2O [RN:R09866]
Reaction(KEGG)
Substrate
ent-cassa-12,15-diene [CPD:C18226];
O2 [CPD:C00007];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
ent-11beta-hydroxycassa-12,15-diene [CPD:C20150];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
Requires cytochrome P450. A rice, Oryza sativa, enzyme involved in the biosynthesis of the antifungal phytocassanes.
History
EC 1.14.13.145 created 2012
Pathway
Diterpenoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K16084  
ent-cassa-12,15-diene 11-hydroxylase
Genes
OSA: 
4329722(CYP76M8) 4329723 4341447(CYP76M7)
DOSA: 
Os02t0569400-01(Os02g0569400) Os02t0569900-01(Os02g0569900) Os06t0599200-01(Os06g0599200)
Taxonomy
Reference
1  [PMID:19825834]
  Authors
Swaminathan S, Morrone D, Wang Q, Fulton DB, Peters RJ
  Title
CYP76M7 is an ent-cassadiene C11alpha-hydroxylase defining a second multifunctional diterpenoid biosynthetic gene cluster in rice.
  Journal
Plant. Cell. 21 (2009) 3315-25.
  Sequence
[osa:4329723]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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