KEGG   ENZYME: 1.14.13.147Help
Entry
EC 1.14.13.147              Enzyme                                 

Name
taxoid 7beta-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
taxusin,NADPH:oxygen 7-oxidoreductase
Reaction(IUBMB)
taxusin + O2 + NADPH + H+ = 7beta-hydroxytaxusin + NADP+ + H2O [RN:R09868]
Reaction(KEGG)
Substrate
taxusin [CPD:C20152];
O2 [CPD:C00007];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
7beta-hydroxytaxusin [CPD:C20153];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
Requires cytochrome P-450. From the yew tree Taxus cuspidata. Does not act on earlier intermediates in taxol biosynthesis.
History
EC 1.14.13.147 created 2012
Reference
1  [PMID:15157877]
  Authors
Chau M, Jennewein S, Walker K, Croteau R
  Title
Taxol biosynthesis: Molecular cloning and characterization of a cytochrome P450 taxoid 7 beta-hydroxylase.
  Journal
Chem. Biol. 11 (2004) 663-72.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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