KEGG   ENZYME: 1.14.13.150Help
Entry
EC 1.14.13.150              Enzyme                                 

Name
alpha-humulene 10-hydroxylase;
CYP71BA1
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
alpha-humulene,NADPH:oxygen 10-oxidoreductase
Reaction(IUBMB)
alpha-humulene + O2 + NADPH + H+ = 10-hydroxy-alpha-humulene + NADP+ + H2O [RN:R09934]
Reaction(KEGG)
Substrate
alpha-humulene [CPD:C09684];
O2 [CPD:C00007];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
10-hydroxy-alpha-humulene [CPD:C20229];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
Requires cytochrome P-450. The recommended numbering of humulene gives 10-hydroxy-alpha-humulene as the product rather than 8-hydroxy-alpha-humulene as used by the reference. See {iupac/sectionF/index::Section F: Natural Product Nomenclature}.
History
EC 1.14.13.150 created 2012
Reference
1  [PMID:20730551]
  Authors
Yu F, Okamoto S, Harada H, Yamasaki K, Misawa N, Utsumi R
  Title
Zingiber zerumbet CYP71BA1 catalyzes the conversion of alpha-humulene to 8-hydroxy-alpha-humulene in zerumbone biosynthesis.
  Journal
Cell. Mol. Life. Sci. 68 (2011) 1033-40.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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