KEGG   ENZYME: 1.14.13.151Help
Entry
EC 1.14.13.151              Enzyme                                 

Name
linalool 8-monooxygenase;
P-450lin;
CYP111
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
linalool,NADH:oxygen oxidoreductase (8-hydroxylating)
Reaction(IUBMB)
linalool + 2 NADH + 2 H+ + 2 O2 = (6E)-8-oxolinalool + 2 NAD+ + 3 H2O (overall reaction) [RN:R09925];
(1a) linalool + NADH + H+ + O2 = (6E)-8-hydroxylinalool + NAD+ + H2O [RN:R04366];
(1b) (6E)-8-hydroxylinalool + NADH + H+ + O2 = (6E)-8-oxolinalool + NAD+ + 2 H2O [RN:R09924]
Reaction(KEGG)
Substrate
linalool [CPD:C03985];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007];
(6E)-8-hydroxylinalool [CPD:C04433]
Product
(6E)-8-oxolinalool [CPD:C20221];
NAD+ [CPD:C00003];
H2O [CPD:C00001];
(6E)-8-hydroxylinalool [CPD:C04433]
Comment
A heme-thiolate protein (P-450). The secondary electron donor is a specific [2Fe-2S] ferredoxin from the same bacterial strain.
History
EC 1.14.13.151 created 1989 as EC 1.14.99.28, transferred 2012 to EC 1.14.13.151
Pathway
Monoterpenoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K05525  
linalool 8-monooxygenase
Genes
ACI: 
ACIAD1575(linC)
SUR: 
PLA: 
NAR: 
Taxonomy
Reference
1  [PMID:2295633]
  Authors
Ullah AJ, Murray RI, Bhattacharyya PK, Wagner GC, Gunsalus IC
  Title
Protein components of a cytochrome P-450 linalool 8-methyl hydroxylase.
  Journal
J. Biol. Chem. 265 (1990) 1345-51.
Reference
2  [PMID:8376348]
  Authors
Ropp JD, Gunsalus IC, Sligar SG
  Title
Cloning and expression of a member of a new cytochrome P-450 family: cytochrome P-450lin (CYP111) from Pseudomonas incognita.
  Journal
J. Bacteriol. 175 (1993) 6028-37.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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