KEGG   ENZYME: 1.14.13.167Help
Entry
EC 1.14.13.167              Enzyme                                 

Name
4-nitrophenol 4-monooxygenase;
pnpA (gene name);
pdcA (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
4-nitrophenol,NAD(P)H:oxygen 4-oxidoreductase (4-hydroxylating, nitrite-forming)
Reaction(IUBMB)
4-nitrophenol + NADPH + H+ + O2 = 1,4-benzoquinone + nitrite + NADP+ + H2O [RN:R05258]
Reaction(KEGG)
Substrate
4-nitrophenol [CPD:C00870];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
1,4-benzoquinone [CPD:C00472];
nitrite [CPD:C00088];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
Contains FAD. The enzyme catalyses the first step in a degradation pathway for 4-nitrophenol, the oxidation of 4-nitrophenol at position 4 with the concomitant removal of the nitro group as nitrite. The enzyme from the bacterium Pseudomonas sp. strain WBC-3 also catalyses EC 1.14.13.166, 4-nitrocatechol 4-monooxygenase.
History
EC 1.14.13.167 created 2012
Pathway
Aminobenzoate degradation
Microbial metabolism in diverse environments
Reference
1  [PMID:19218392]
  Authors
Zhang JJ, Liu H, Xiao Y, Zhang XE, Zhou NY
  Title
Identification and characterization of catabolic para-nitrophenol 4-monooxygenase and para-benzoquinone reductase from Pseudomonas sp. strain WBC-3.
  Journal
J. Bacteriol. 191 (2009) 2703-10.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system