KEGG   ENZYME: 1.14.13.174Help
Entry
EC 1.14.13.174              Enzyme                                 

Name
averantin hydroxylase;
AVN hydroxylase;
avnA (gene name);
(1'S)-averantin,NADPH:O2 oxidoreductase (5'-hydroxylating)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
(1'S)-averantin,NADPH:oxygen oxidoreductase (5'-hydroxylating)
Reaction(IUBMB)
(1) (1'S)-averantin + NADPH + H+ + O2 = (1'S,5'S)-5'-hydroxyaverantin + NADP+ + H2O [RN:R10317];
(2) (1'S)-averantin + NADPH + H+ + O2 = (1'S,5'R)-5'-hydroxyaverantin + NADP+ + H2O [RN:R10318]
Reaction(KEGG)
Substrate
(1'S)-averantin [CPD:C20499];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
(1'S,5'S)-5'-hydroxyaverantin [CPD:C20500];
NADP+ [CPD:C00006];
H2O [CPD:C00001];
(1'S,5'R)-5'-hydroxyaverantin [CPD:C20501]
Comment
A heme-thiolate (P-450) monooxygenase isolated from Aspergillus parasiticus. There is no reaction with (1'R)-averantin. Involved in aflatoxin biosynthesis.
History
EC 1.14.13.174 created 2013
Pathway
Aflatoxin biosynthesis
Orthology
K17645  
averantin hydroxylase
Genes
PAN: 
ANI: 
AOR: 
AOR_1_48014(AO090026000021)
AFV: 
Taxonomy
Reference
1  [PMID:8368836]
  Authors
Yabe K, Matsuyama Y, Ando Y, Nakajima H, Hamasaki T
  Title
Stereochemistry during aflatoxin biosynthesis: conversion of norsolorinic acid to averufin.
  Journal
Appl. Environ. Microbiol. 59 (1993) 2486-92.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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