KEGG   ENZYME: 1.14.13.176Help
Entry
EC 1.14.13.176              Enzyme                                 

Name
tryprostatin B 6-hydroxylase;
ftmC (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
tryprostatin B,NADPH:oxygen oxidoreductase (6-hydroxytryprostatin B-forming)
Reaction(IUBMB)
tryprostatin B + NADPH + H+ + O2 = 6-hydroxytryprostatin B + NADP+ + H2O [RN:R10321]
Reaction(KEGG)
Substrate
tryprostatin B [CPD:C20512];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
6-hydroxytryprostatin B [CPD:C20513];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450). Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, fumitremorgins and verruculogen.
History
EC 1.14.13.176 created 2013
Pathway
Staurosporine biosynthesis
Biosynthesis of antibiotics
Orthology
K17475  
tryprostatin B 6-hydroxylase
Genes
TRE: 
ANI: 
AFM: 
AOR: 
AOR_1_732174(AO090005000422)
ANG: 
ANI_1_1612064(An07g02570) ANI_1_2140184(An04g08440) ANI_1_428054(An06g00760)
AFV: 
ACT: 
NFI: 
CIM: 
ZTR: 
Taxonomy
Reference
1  [PMID:19226505]
  Authors
Kato N, Suzuki H, Takagi H, Asami Y, Kakeya H, Uramoto M, Usui T, Takahashi S, Sugimoto Y, Osada H
  Title
Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus.
  Journal
Chembiochem. 10 (2009) 920-8.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system