KEGG   ENZYME: 1.14.13.177Help
Entry
EC 1.14.13.177              Enzyme                                 

Name
fumitremorgin C monooxygenase;
ftmG (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
fumitremorgin C,NADPH:oxygen oxidoreductase (12alpha,13alpha-dihydroxyfumitremorgin C-forming)
Reaction(IUBMB)
fumitremorgin C + 2 NADPH + 2 H+ + 2 O2 = 12alpha,13alpha-dihydroxyfumitremorgin C + 2 NADP+ + 2 H2O [RN:R10414]
Reaction(KEGG)
Substrate
fumitremorgin C [CPD:C20604];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
12alpha,13alpha-dihydroxyfumitremorgin C [CPD:C20605];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450). Involved in the biosynthetic pathway of the indole alkaloid verruculogen.
History
EC 1.14.13.177 created 2013
Pathway
Staurosporine biosynthesis
Biosynthesis of antibiotics
Orthology
K17826  
fumitremorgin C monooxygenase
Genes
AFM: 
NFI: 
PCS: 
Taxonomy
Reference
1  [PMID:19226505]
  Authors
Kato N, Suzuki H, Takagi H, Asami Y, Kakeya H, Uramoto M, Usui T, Takahashi S, Sugimoto Y, Osada H
  Title
Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus.
  Journal
Chembiochem. 10 (2009) 920-8.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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