KEGG   ENZYME: 1.14.13.189Help
Entry
EC 1.14.13.189              Enzyme                                 

Name
5-methyl-1-naphthoate 3-hydroxylase;
AziB1
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
5-methyl-1-naphthoate,NADPH:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
5-methyl-1-naphthoate + NADPH + H+ + O2 = 3-hydroxy-5-methyl-1-naphthoate + NADP+ + H2O [RN:R10725]
Reaction(KEGG)
Substrate
5-methyl-1-naphthoate [CPD:C20803];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
3-hydroxy-5-methyl-1-naphthoate [CPD:C20805];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
The enzyme from the bacterium Streptomyces sahachiroi is involved in the biosynthesis of 3-methoxy-5-methyl-1-naphthoate, a component of of the the antitumor antibiotic azinomycin B.
History
EC 1.14.13.189 created 2014
Orthology
K21376  
5-methyl-1-naphthoate 3-hydroxylase
Reference
1  [PMID:20485749]
  Authors
Ding W, Deng W, Tang M, Zhang Q, Tang G, Bi Y, Liu W
  Title
Biosynthesis of 3-methoxy-5-methyl naphthoic acid and its incorporation into the  antitumor antibiotic azinomycin B.
  Journal
Mol. Biosyst. 6 (2010) 1071-81.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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