| Entry |
|
|---|
| Name |
taxifolin 8-monooxygenase;
taxifolin hydroxylase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With NADH or NADPH as one donor, and incorporation of one atom of
oxygen into the other donor
 |
|---|
| Sysname |
taxifolin,NAD(P)H:oxygen oxidoreductase (8-hydroxylating) |
|---|
| Reaction(IUBMB) |
taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ +
H2O [RN:R03637 R03638] |
|---|
| Reaction(KEGG) |
R03637 R03638
 |
|---|
| Substrate |
taxifolin [CPD:C01617];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007] |
|---|
| Product |
2,3-dihydrogossypetin [CPD:C03052];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001] |
|---|
| Cofactor |
FAD [CPD:C00016];
Flavoprotein [CPD:C06411] |
|---|
| Comment |
A flavoprotein, converting a flavanol into a flavanone. Also acts on
fustin, but not on catechin, quercetin or mollisacidin. |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4146277]
Jeffrey AM, Knight M, Evans WC.
The bacterial degradation of flavonoids. Hydroxylation of the A-ring
of taxifolin by a soil pseudomonad.
Biochem. J. 130 (1972) 373-81.
Pseudomonas sp. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.13.19
IUBMB Enzyme Nomenclature: 1.14.13.19
ExPASy - ENZYME nomenclature database: 1.14.13.19
BRENDA, the Enzyme Database: 1.14.13.19
CAS: 39307-19-2 |
|---|
