KEGG   ENZYME: 1.14.13.191Help
Entry
EC 1.14.13.191              Enzyme                                 

Name
ent-sandaracopimaradiene 3-hydroxylase;
CYP701A;
OsKOL4
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
ent-sandaracopimaradiene,NADPH:oxygen oxidoreductase (ent-sandaracopimaradien-3beta-ol forming)
Reaction(IUBMB)
ent-sandaracopimaradiene + NADPH + H+ + O2 = ent-sandaracopimaradien-3beta-ol + NADP+ + H2O [RN:R11656]
Reaction(KEGG)
Substrate
ent-sandaracopimaradiene [CPD:C11877];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
ent-sandaracopimaradien-3beta-ol [CPD:C21560];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (cytochrome P-450). Isolated from Oryza sativa (rice). Participates in the pathway for the biosynthesis of oryzalexins, a group of related phytoalexins produced by rice.
History
EC 1.14.13.191 created 2014
Orthology
K21719  
ent-sandaracopimaradiene 3-hydroxylase
Genes
OSA: 
4341343(CYP701A8)
DOSA: 
Os06t0569500-01(Os06g0569500)
OBR: 
Taxonomy
Reference
1  [PMID:22247270]
  Authors
Wang Q, Hillwig ML, Wu Y, Peters RJ
  Title
CYP701A8: a rice ent-kaurene oxidase paralog diverted to more specialized diterpenoid metabolism.
  Journal
Plant. Physiol. 158 (2012) 1418-25.
  Sequence
[osa:4341343]
Reference
2  [PMID:23795884]
  Authors
Wu Y, Wang Q, Hillwig ML, Peters RJ
  Title
Picking sides: distinct roles for CYP76M6 and CYP76M8 in rice oryzalexin biosynthesis.
  Journal
Biochem. J. 454 (2013) 209-16.
  Sequence
[osa:4341343]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system