KEGG   ENZYME: 1.14.13.193Help
Entry
EC 1.14.13.193              Enzyme                                 

Name
oryzalexin D synthase;
CYP76M8
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
ent-sandaracopimaradien-3beta-ol,NADPH:oxygen oxidoreductase (oryzalexin D forming)
Reaction(IUBMB)
ent-sandaracopimaradien-3beta-ol + NADPH + H+ + O2 = oryzalexin D + NADP+ + H2O [RN:R11658]
Reaction(KEGG)
Substrate
ent-sandaracopimaradien-3beta-ol [CPD:C21560];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
oryzalexin D [CPD:C21562];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (cytochrome P-450). Isolated from Oryza sativa (rice). Oryzalexin D is a phytoalexin.
History
EC 1.14.13.193 created 2014
Orthology
K16084  
ent-cassa-12,15-diene 11-hydroxylase / oryzalexin D synthase
Genes
OSA: 
4329722(CYP76M8) 4329723 4341447(CYP76M7)
DOSA: 
Os02t0569400-01(Os02g0569400) Os02t0569900-01(Os02g0569900) Os06t0599200-01(Os06g0599200)
Taxonomy
Reference
1  [PMID:23795884]
  Authors
Wu Y, Wang Q, Hillwig ML, Peters RJ
  Title
Picking sides: distinct roles for CYP76M6 and CYP76M8 in rice oryzalexin biosynthesis.
  Journal
Biochem. J. 454 (2013) 209-16.
  Sequence
[osa:4329722]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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