KEGG   ENZYME: 1.14.13.194Help
Entry
EC 1.14.13.194              Enzyme                                 

Name
phylloquinone omega-hydroxylase;
vitamin K1 omega-hydroxylase;
CYP4F2;
CYP4F11
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
phylloquinone,NADPH:oxygen oxidoreductase (omega-hydroxyphylloquinone forming)
Reaction(IUBMB)
phylloquinone + NADPH + H+ + O2 = omega-hydroxyphylloquinone + NADP+ + H2O [RN:R10728]
Reaction(KEGG)
Substrate
phylloquinone [CPD:C02059];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
omega-hydroxyphylloquinone [CPD:C20806];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (cytochrome P-450). Isolated from human tissue. The enzyme will also act on menaquinone-4. Prolonged action of CYP4F2, but not CYP4F11, on the omega hydroxyl group oxidizes it to the corresponding carboxylic acid. CYP4F2 also oxidizes leukotriene B4; see EC 1.14.13.30, leukotriene-B4 20-monooxygenase [1].
History
EC 1.14.13.194 created 2014
Orthology
K17726  
leukotriene-B4 20-monooxygenase / phylloquinone omega-hydroxylase
K17729  
cytochrome P450, family 4, subfamily F, polypeptide 11
Genes
HSA: 
4051(CYP4F3) 57834(CYP4F11) 8529(CYP4F2)
PTR: 
PPS: 
GGO: 
PON: 
100174280(CYP4F11)
NLE: 
MCC: 
MCF: 
102120579 102130440(CYP4F3v2) 102134301(CYP4F45) 102135027(CYP4F11)
RRO: 
CJC: 
MMU: 
170716(Cyp4f13) 64385(Cyp4f14) 72054(Cyp4f18)
RNO: 
266689(Cyp4f6) 290623(Cyp4f18) 56266(Cyp4f1)
CGE: 
NGI: 
HGL: 
OCU: 
TUP: 
CFA: 
AML: 
UMR: 
FCA: 
PTG: 
BTA: 
100295883 507016(CYP4F2) 507615(CYP4F2) 534967(CYP4F3)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
100113470(CYP4F2) 100620559(CYP4F55)
CFR: 
LVE: 
ECB: 
MYB: 
MYD: 
MDO: 
SHR: 
PHI: 
DRE: 
100037390(cyp4f3)
TRU: 
MZE: 
OLA: 
BFO: 
LGI: 
 » show all
Taxonomy
Reference
1  [PMID:9799565]
  Authors
Jin R, Koop DR, Raucy JL, Lasker JM
  Title
Role of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4.
  Journal
Arch. Biochem. Biophys. 359 (1998) 89-98.
  Sequence
[hsa:8529]
Reference
2  [PMID:19932081]
  Authors
Tang Z, Salamanca-Pinzon SG, Wu ZL, Xiao Y, Guengerich FP
  Title
Human cytochrome P450 4F11: heterologous expression in bacteria, purification, and characterization of catalytic function.
  Journal
Arch. Biochem. Biophys. 494 (2010) 86-93.
  Sequence
[hsa:57834]
Reference
3  [PMID:24138531]
  Authors
Edson KZ, Prasad B, Unadkat JD, Suhara Y, Okano T, Guengerich FP, Rettie AE
  Title
Cytochrome P450-dependent catabolism of vitamin K: omega-hydroxylation catalyzed  by human CYP4F2 and CYP4F11.
  Journal
Biochemistry. 52 (2013) 8276-85.
  Sequence
[hsa:8529 57834]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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