KEGG   ENZYME: 1.14.13.198Help
Entry
EC 1.14.13.198              Enzyme                                 

Name
monacolin L hydroxylase;
LovA (ambiguous)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
monacolin L acid,NADPH:oxygen oxidoreductase (8-hydroxylating)
Reaction(IUBMB)
monacolin L acid + O2 + NADPH + H+ = monacolin J acid + NADP+ + H2O [RN:R10794]
Reaction(KEGG)
Substrate
monacolin L acid [CPD:C20853];
O2 [CPD:C00007];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
monacolin J acid [CPD:C20854];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (cytochrome P-450). The enzyme from fungi also catalyses the reaction of EC 1.14.13.197, dihydromonacolin L hydroxylase.
History
EC 1.14.13.198 created 2014
Orthology
K20980  
dihydromonacolin L/monacolin L hydroxylase
Reference
1  [PMID:21495633]
  Authors
Barriuso J, Nguyen DT, Li JW, Roberts JN, MacNevin G, Chaytor JL, Marcus SL, Vederas JC, Ro DK
  Title
Double oxidation of the cyclic nonaketide dihydromonacolin L to monacolin J by a  single cytochrome P450 monooxygenase, LovA.
  Journal
J. Am. Chem. Soc. 133 (2011) 8078-81.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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