KEGG   ENZYME: 1.14.13.199Help
Entry
EC 1.14.13.199              Enzyme                                 

Name
docosahexaenoic acid omega-hydroxylase;
CYP4F3B;
CYP4V2;
docosahexaenoate,NADPH:O2 oxidoreductase (22-hydroxydocosahexaenoate forming)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
docosahexaenoate,NADPH:oxygen oxidoreductase (22-hydroxydocosahexaenoate forming)
Reaction(IUBMB)
docosahexaenoate + NADPH + H+ + O2 = 22-hydroxydocosahexaenoate + NADP+ + H2O [RN:R10795]
Reaction(KEGG)
Substrate
docosahexaenoate [CPD:C06429];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
22-hydroxydocosahexaenoate [CPD:C20855];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
Isolated from human eye tissue. Defects in the enzyme are associated with Bietti crystalline corneoretinal dystrophy. The enzyme also produces some 21-hydroxydocosahexaenoate. Acts in a similar way on icosapentaenoic acid.
History
EC 1.14.13.199 created 2014
Reference
1  [PMID:22772592]
  Authors
Nakano M, Kelly EJ, Wiek C, Hanenberg H, Rettie AE
  Title
CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of omega-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant.
  Journal
Mol. Pharmacol. 82 (2012) 679-86.
  Sequence
[hsa:285440]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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