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Entry
EC 1.14.13.20               Enzyme                                 
Name
2,4-dichlorophenol 6-monooxygenase;
2,4-dichlorophenol hydroxylase;
2,4-dichlorophenol monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
2,4-dichlorophenol,NADPH:oxygen oxidoreductase (6-hydroxylating)
Reaction(IUBMB)
2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O [RN:R03997]
Reaction(KEGG)
R03997;
(other) R05441
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Substrate
2,4-dichlorophenol [CPD:C02625];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
3,5-dichlorocatechol [CPD:C02933];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD). Also acts, more slowly, on 4-chlorophenol and 4-chloro-2-methylphenol; NADH can act instead of NADPH, but more slowly.
Pathway
Chlorocyclohexane and chlorobenzene degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K10676  
2,4-dichlorophenol 6-monooxygenase
Genes
PPUH: 
PDR: 
ACD: 
ACB: 
REU: 
CNC: 
BMU: 
BMJ: 
BCT: 
BYI: 
BPT: 
Bpet1331
AXY: 
AXYL_03121
ADN: 
Alide_3930
ADK: 
Alide2_4275
DAR: 
Daro_0899
MCI: 
Mesci_5342
AVI: 
Avi_7439
RLE: 
pRL120094(tfdB)
RLG: 
Rleg_5534
BRA: 
BRADO2271(tfdB)
MSL: 
Msil_1463
PHL: 
KKY_3150
OAT: 
OAN307_c31200
SWI: 
Swit_2298 Swit_3045
SJP: 
SJA_C1-21170(tfdB)
MVA: 
Mvan_4406
CEF: 
CE2219
CHN: 
A605_00660 A605_12305
RHA: 
RHA1_ro00520(ohpB) RHA1_ro00538 RHA1_ro10313
ROP: 
ROP_46190
SCB: 
SCAB_12351 SCAB_14111
SVL: 
Strvi_3710 Strvi_4586
SHY: 
SHJG_8539
SHO: 
SHJGH_8299
SDV: 
BN159_1741
ART: 
Arth_1929
ACH: 
Achl_4564
NML: 
Namu_0227
AMD: 
AMED_5991
AMN: 
RAM_30725
AMM: 
AMES_5907
 » show all
Taxonomy
Reference
1  [PMID:7075592]
  Authors
Beadle CA, Smith AR.
  Title
The purification and properties of 2,4-dichlorophenol hydroxylase from a strain of Acinetobacter species.
  Journal
Eur. J. Biochem. 123 (1982) 323-32.
  Organism
Acinetobacter sp.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
82047-82-3
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