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Entry
EC 1.14.13.20               Enzyme                                 

Name
2,4-dichlorophenol 6-monooxygenase;
2,4-dichlorophenol hydroxylase;
2,4-dichlorophenol monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
2,4-dichlorophenol,NADPH:oxygen oxidoreductase (6-hydroxylating)
Reaction(IUBMB)
2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O [RN:R03997]
Reaction(KEGG)
R03997;
(other) R05441
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Substrate
2,4-dichlorophenol [CPD:C02625];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
3,5-dichlorocatechol [CPD:C02933];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD). Also acts, more slowly, on 4-chlorophenol and 4-chloro-2-methylphenol; NADH can act instead of NADPH, but more slowly.
History
EC 1.14.13.20 created 1983
Pathway
ec00361  Chlorocyclohexane and chlorobenzene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K10676  2,4-dichlorophenol 6-monooxygenase
Genes
PCQ: PcP3B5_21640(tfdB)
PPUH: B479_25850
PDR: H681_09635
PSV: PVLB_26087
ACB: A1S_1079
ACD: AOLE_13995
AEI: AOY20_13805
REU: Reut_B4679 Reut_D6462 Reut_D6470
CNC: CNE_BB2p00380(tfdB)
BCEN: DM39_5592(tfdB)
BMU: Bmul_2460
BCT: GEM_2096
BPSL: WS57_14635
BYI: BYI23_F000530(mhqA) BYI23_F000610(mhqA)
BPT: Bpet1331
DAR: Daro_0899
SIX: BSY16_5886(tfdB)
AVI: Avi_7439
AGC: BSY240_3583(tfdB)
RLE: pRL120094(tfdB)
RLG: Rleg_5534
RHL: LPU83_3293(tfdB)
SHZ: shn_17085
BRA: BRADO2271(tfdB)
BRO: BRAD285_6478(tfdB)
MSL: Msil_1463
PHL: KKY_3150
MMED: Mame_00353(tfdB_1)
SJP: SJA_C1-21170(tfdB)
SINB: SIDU_04775
MVA: Mvan_4406
CEF: CE2219
CDX: CDES_03630(tfdB)
ROP: ROP_46190
SHY: SHJG_8539
SLE: sle_04010(sle_04010)
ART: Arth_1929
ACH: Achl_4564
PSIM: KR76_25500
NML: Namu_0227
AMD: AMED_5991
AMN: RAM_30725
AMM: AMES_5907
AMZ: B737_5907
PSEA: WY02_07855
PSEH: XF36_06625
AFS: AFR_25335
 » show all
Taxonomy
Reference
1  [PMID:7075592]
  Authors
Beadle CA, Smith AR.
  Title
The purification and properties of 2,4-dichlorophenol hydroxylase from a strain of Acinetobacter species.
  Journal
Eur. J. Biochem. 123 (1982) 323-32.
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.20
IUBMB Enzyme Nomenclature: 1.14.13.20
ExPASy - ENZYME nomenclature database: 1.14.13.20
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.20
BRENDA, the Enzyme Database: 1.14.13.20
CAS: 82047-82-3

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