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Entry
EC 1.14.13.20               Enzyme                                 

Name
2,4-dichlorophenol 6-monooxygenase;
2,4-dichlorophenol hydroxylase;
2,4-dichlorophenol monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
2,4-dichlorophenol,NADPH:oxygen oxidoreductase (6-hydroxylating)
Reaction(IUBMB)
2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O [RN:R03997]
Reaction(KEGG)
R03997;
(other) R05441
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Substrate
2,4-dichlorophenol [CPD:C02625];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
3,5-dichlorocatechol [CPD:C02933];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD). Also acts, more slowly, on 4-chlorophenol and 4-chloro-2-methylphenol; NADH can act instead of NADPH, but more slowly.
History
EC 1.14.13.20 created 1983
Pathway
Chlorocyclohexane and chlorobenzene degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K10676  
2,4-dichlorophenol 6-monooxygenase
Genes
PPUH: 
PDR: 
PSV: 
ACB: 
ACD: 
AEI: 
REU: 
CNC: 
BCEN: 
DM39_5592(tfdB)
BMU: 
BMJ: 
BCT: 
BYI: 
BPT: 
AXY: 
ADN: 
ADK: 
DAR: 
MCI: 
AVI: 
RLE: 
pRL120094(tfdB)
RLG: 
RHL: 
SHZ: 
BRA: 
BRADO2271(tfdB)
MSL: 
PHL: 
OAT: 
SWI: 
SJP: 
MVA: 
CEF: 
CHN: 
CMD: 
CHM: 
CDX: 
RHA: 
REB: 
ROP: 
ROA: 
RPY: 
RAV: 
SCB: 
SVL: 
SHY: 
SHO: 
SDV: 
SCW: 
SXI: 
STRC: 
SCX: 
MVD: 
FRP: 
ART: 
ACH: 
KPL: 
PSIM: 
NML: 
AMD: 
AMN: 
AMM: 
AMZ: 
AMQ: 
PSEA: 
PSEH: 
KPHY: 
AFS: 
 » show all
Taxonomy
Reference
1  [PMID:7075592]
  Authors
Beadle CA, Smith AR.
  Title
The purification and properties of 2,4-dichlorophenol hydroxylase from a strain of Acinetobacter species.
  Journal
Eur. J. Biochem. 123 (1982) 323-32.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
82047-82-3

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