KEGG   ENZYME: 1.14.13.205Help
Entry
EC 1.14.13.205              Enzyme                                 

Name
long-chain fatty acid omega-monooxygenase;
CYP704B1 (gene name);
CYP52M1 (gene name);
CYP4A (gene name);
CYP86A (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
long-chain fatty acid,NADPH:oxygen oxidoreductase (omega-hydroxylating)
Reaction(IUBMB)
a long-chain fatty acid + NADPH + H+ + O2 = an omega-hydroxy-long-chain fatty acid + NADP+ + H2O
Substrate
long-chain fatty acid [CPD:C00638];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
omega-hydroxy-long-chain fatty acid;
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
The plant enzyme CYP704B1, which is involved in the synthesis of sporopollenin, a complex polymer found at the outer layer of spores and pollen, acts on palmitate (18:0), stearate (18:0) and oleate (18:1). The plant enzyme CYP86A1 also acts on laurate (12:0). The enzyme from the yeast Starmerella bombicola (CYP52M1) acts on C16 to C20 saturated and unsaturated fatty acids and can also hydroxylate the (omega-1) position. The mammalian enzyme CYP4A acts on laurate (12:0), myristate (14:0), palmitate (16:0), oleate (18:1), and arachidonate (20:4).
History
EC 1.14.13.205 created 2015
Orthology
K20495  
long-chain fatty acid omega-monooxygenase
Genes
ATH: 
AT1G69500(CYP704B1)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj3g3v2576010.1(Lj3g3v2576010.1)
FVE: 
PPER: 
PMUM: 
MDM: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
POPTR_0008s08840g(POPTRDRAFT_564227) POPTR_0010s17370g(POPTRDRAFT_81575)
VVI: 
SLY: 
SPEN: 
SOT: 
SIND: 
BVG: 
NNU: 
OSA: 
DOSA: 
Os03t0168600-01(Os03g0168600)
OBR: 
BDI: 
ATS: 
SBI: 
SORBI_01g045960(SORBIDRAFT_01g045960)
ZMA: 
100191749(ms26)
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
ACAN: 
PSOJ: 
 » show all
Taxonomy
Reference
1  [PMID:9500987]
  Authors
Benveniste I, Tijet N, Adas F, Philipps G, Salaun JP, Durst F
  Title
CYP86A1 from Arabidopsis thaliana encodes a cytochrome P450-dependent fatty acid  omega-hydroxylase.
  Journal
Biochem. Biophys. Res. Commun. 243 (1998) 688-93.
Reference
2  [PMID:10620324]
  Authors
Hoch U, Zhang Z, Kroetz DL, Ortiz de Montellano PR
  Title
Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylases.
  Journal
Arch. Biochem. Biophys. 373 (2000) 63-71.
Reference
3  [PMID:19700560]
  Authors
Dobritsa AA, Shrestha J, Morant M, Pinot F, Matsuno M, Swanson R, Moller BL, Preuss D
  Title
CYP704B1 is a long-chain fatty acid omega-hydroxylase essential for sporopollenin synthesis in pollen of Arabidopsis.
  Journal
Plant. Physiol. 151 (2009) 574-89.
  Sequence
[ath:AT1G69500]
Reference
4  [PMID:24242247]
  Authors
Huang FC, Peter A, Schwab W
  Title
Expression and characterization of CYP52 genes involved in the biosynthesis of sophorolipid and alkane metabolism from Starmerella bombicola.
  Journal
Appl. Environ. Microbiol. 80 (2014) 766-76.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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