KEGG   ENZYME: 1.14.13.27Help
Entry
EC 1.14.13.27               Enzyme                                 

Name
4-aminobenzoate 1-monooxygenase;
4-aminobenzoate hydroxylase;
4-aminobenzoate monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
4-aminobenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)
Reaction(IUBMB)
4-aminobenzoate + NAD(P)H + 2 H+ + O2 = 4-hydroxyaniline + NAD(P)+ + H2O + CO2 [RN:R02561 R02562]
Reaction(KEGG)
Substrate
4-aminobenzoate [CPD:C00568];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
4-hydroxyaniline [CPD:C02372];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001];
CO2 [CPD:C00011]
Comment
A flavoprotein (FAD). Acts on anthranilate and 4-aminosalicylate but not on salicylate (cf. EC 1.14.13.1 salicylate 1-monooxygenase).
History
EC 1.14.13.27 created 1989
Pathway
Aminobenzoate degradation
Microbial metabolism in diverse environments
Reference
1  [PMID:3489713]
  Authors
Tsuji H, Ogawa T, Bando N, Sasaoka K.
  Title
Purification and properties of 4-aminobenzoate hydroxylase, a new monooxygenase from Agaricus bisporus.
  Journal
J. Biol. Chem. 261 (1986) 13203-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
98668-55-4

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