KEGG   ENZYME: 1.14.13.37Help
Entry
EC 1.14.13.37               Enzyme                                 

Name
methyltetrahydroprotoberberine 14-monooxygenase;
methyltetrahydroprotoberberine 14-hydroxylase;
(S)-cis-N-methyltetrahydroberberine 14-monooxygenase;
(S)-cis-N-methyltetrahydroprotoberberine-14-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
(S)-N-methylcanadine,NADPH:oxygen oxidoreductase (14-hydroxylating)
Reaction(IUBMB)
(S)-N-methylcanadine + NADPH + H+ + O2 = allocryptopine + NADP+ + H2O [RN:R03842]
Reaction(KEGG)
R03842;
(other) R04700
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Substrate
(S)-N-methylcanadine;
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
allocryptopine [CPD:C02134];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450).
History
EC 1.14.13.37 created 1990
Pathway
Isoquinoline alkaloid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K21692  
methyltetrahydroprotoberberine 14-monooxygenase
Reference
1
  Authors
Rueffer, M. and Zenk, M.H.
  Title
Enzymatic formation of protopines by a microsomal cytochrome-P-450 system of Corydalis vaginans.
  Journal
Tetrahedron Lett. 28 (1987) 5307-5310.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
113478-42-5

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