KEGG   ENZYME: 1.14.13.38Help
Entry
EC 1.14.13.38               Enzyme                                 

Name
anhydrotetracycline monooxygenase;
ATC oxygenase;
anhydrotetracycline oxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
anhydrotetracycline,NADPH:oxygen oxidoreductase (6-hydroxylating)
Reaction(IUBMB)
anhydrotetracycline + NADPH + H+ + O2 = 12-dehydrotetracycline + NADP+ + H2O [RN:R04060]
Reaction(KEGG)
R04060;
(other) R09193
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Substrate
anhydrotetracycline [CPD:C02811];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
12-dehydrotetracycline [CPD:C03206];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
Involved in the biosynthesis of the antibiotics tetracyclines in Streptomyces sp.
History
EC 1.14.13.38 created 1990
Pathway
Tetracycline biosynthesis
Biosynthesis of type II polyketide products
Biosynthesis of antibiotics
Orthology
K14256  
anhydrotetracycline monooxygenase
Reference
1
  Authors
Behal, V.
  Title
The tetracycline fermentation and its regulation.
  Journal
CRC Crit. Rev. Biotechnol. 5 (1987) 295-318.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
70766-62-0

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