| Entry |
|
|---|
| Name |
anthraniloyl-CoA monooxygenase;
anthraniloyl coenzyme A reductase;
2-aminobenzoyl-CoA monooxygenase/reductase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With NADH or NADPH as one donor, and incorporation of one atom of
oxygen into the other donor
 |
|---|
| Sysname |
2-aminobenzoyl-CoA,NAD(P)H:oxygen oxidoreductase (de-aromatizing) |
|---|
| Reaction(IUBMB) |
2-aminobenzoyl-CoA + 2 NAD(P)H + 2 H+ + O2 =
2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NAD(P)+ [RN:R03998
R03999] |
|---|
| Reaction(KEGG) |
R03998 R03999
 |
|---|
| Substrate |
2-aminobenzoyl-CoA [CPD:C02247];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007] |
|---|
| Product |
2-amino-5-oxocyclohex-1-enecarboxyl-CoA;
H2O [CPD:C00001];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006] |
|---|
| Cofactor |
FAD [CPD:C00016] |
|---|
| Comment |
A flavoprotein (FAD). The non-aromatic product is unstable and
releases CO2 and NH3, forming 1,4-cyclohexanedione. |
|---|
| Pathway |
PATH: ec00629 Carbazole degradation |
|---|
| Orthology |
KO: K09461 anthraniloyl-CoA monooxygenase |
|---|
| Genes |
REH: H16_A2461(abmA)
AZO: azo1934(abmA)
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:2591379]
Buder R, Fuchs G.
2-Aminobenzoyl-CoA monooxygenase/reductase, a novel type of
flavoenzyme. Purification and some properties of the enzyme.
Eur. J. Biochem. 185 (1989) 629-35.
Pseudomonas sp. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:2591380]
Buder R, Ziegler K, Fuchs G, Langkau B, Ghisla S.
2-Aminobenzoyl-CoA monooxygenase/reductase, a novel type of
flavoenzyme. Studies on the stoichiometry and the course of the
reaction.
Eur. J. Biochem. 185 (1989) 637-43.
Pseudomonas sp. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:2384085]
Langkau B, Ghisla S, Buder R, Ziegler K, Fuchs G.
2-Aminobenzoyl-CoA monooxygenase/reductase, a novel type of
flavoenzyme. Identification of the reaction products.
Eur. J. Biochem. 191 (1990) 365-71.
Pseudomonas sp. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.13.40
IUBMB Enzyme Nomenclature: 1.14.13.40
ExPASy - ENZYME nomenclature database: 1.14.13.40
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.40
BRENDA, the Enzyme Database: 1.14.13.40
CAS: 112692-57-6 |
|---|
