KEGG   ENZYME: 1.14.13.43Help
Entry
EC 1.14.13.43               Enzyme                                 

Name
questin monooxygenase;
questin oxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
questin,NADPH:oxygen oxidoreductase (hydroxylating, anthraquinone-ring-opening)
Reaction(IUBMB)
questin + NADPH + H+ + O2 = demethylsulochrin + NADP+ [RN:R02417]
Reaction(KEGG)
Substrate
questin [CPD:C01448];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
demethylsulochrin [CPD:C15504];
NADP+ [CPD:C00006]
Comment
The enzyme cleaves the anthraquinone ring of questin to form a benzophenone. Involved in the biosynthesis of the seco-anthraquinone (+)-geodin.
History
EC 1.14.13.43 created 1992
Reference
1  [PMID:3182756]
  Authors
Fujii I, Ebizuka Y, Sankawa U.
  Title
A novel anthraquinone ring cleavage enzyme from Aspergillus terreus.
  Journal
J. Biochem. (Tokyo). 103 (1988) 878-83.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
115232-45-6

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