KEGG   ENZYME: 1.14.13.5Help
Entry
EC 1.14.13.5                Enzyme                                 

Name
imidazoleacetate 4-monooxygenase;
imidazoleacetic hydroxylase;
imidazoleacetate hydroxylase;
imidazoleacetic monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
4-imidazoleacetate,NADH:oxygen oxidoreductase (5-hydroxylating)
Reaction(IUBMB)
4-imidazoleacetate + NADH + H+ + O2 = 5-hydroxy-4-imidazoleacetate + NAD+ + H2O [RN:R04066]
Reaction(KEGG)
Substrate
4-imidazoleacetate [CPD:C02835];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
5-hydroxy-4-imidazoleacetate [CPD:C05133];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD).
History
EC 1.14.13.5 created 1965 as EC 1.14.1.5, transferred 1972 to EC 1.14.13.5
Pathway
Histidine metabolism
Reference
1  [PMID:5772468]
  Authors
Maki Y, Yamamoto S, Nozaki M, Hayaishi O.
  Title
Studies on monooxygenases. II. Crystallization and some properties of imidazole acetate monooxygenase.
  Journal
J. Biol. Chem. 244 (1969) 2942-50.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9029-65-6

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