KEGG   ENZYME: 1.14.13.51Help
Entry
EC 1.14.13.51               Enzyme                                 

Name
6-oxocineole dehydrogenase;
6-oxocineole oxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
6-oxocineole,NADPH:oxygen oxidoreductase
Reaction(IUBMB)
6-oxocineole + NADPH + H+ + O2 = 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + NADP+ + H2O [RN:R02995]
Reaction(KEGG)
Substrate
6-oxocineole [CPD:C00848];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one [CPD:C04718];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
The product undergoes non-enzymic cleavage and subsequent ring closure to form the lactone 4,5-dihydro-5,5-dimethyl-4-(3-oxobutyl)furan-2(3H)-one.
History
EC 1.14.13.51 created 1992
Pathway
Monoterpenoid biosynthesis
Biosynthesis of secondary metabolites
Reference
1
  Authors
Williams, D.R., Trudgill, P.W. and Taylor, D.G.
  Title
Metabolism of 1,8-cineole by Rhodococcus species: ring cleavage reactions.
  Journal
J. Gen. Microbiol. 135 (1989) 1957-1967.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
122933-80-6

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