KEGG   ENZYME: 1.14.13.55Help
Entry
EC 1.14.13.55               Enzyme                                 

Name
protopine 6-monooxygenase;
protopine 6-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
protopine,NADPH:oxygen oxidoreductase (6-hydroxylating)
Reaction(IUBMB)
protopine + NADPH + H+ + O2 = 6-hydroxyprotopine + NADP+ + H2O [RN:R04699]
Reaction(KEGG)
Substrate
protopine [CPD:C05189];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
6-hydroxyprotopine [CPD:C05190];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450) involved in benzophenanthridine alkaloid synthesis in higher plants.
History
EC 1.14.13.55 created 1999
Pathway
Isoquinoline alkaloid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Reference
1
  Authors
Tanahashi, T. and Zenk, M.H.
  Title
Elicitor induction and characterization of microsomal protopine-6-hydroxylase, the central enzyme in benzophenanthridine alkaloid biosynthesis.
  Journal
Phytochemistry 29 (1990) 1113-1122.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
128561-60-4

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