KEGG   ENZYME: 1.14.13.56Help
Entry
EC 1.14.13.56               Enzyme                                 

Name
dihydrosanguinarine 10-monooxygenase;
dihydrosanguinarine 10-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
dihydrosanguinarine,NADPH:oxygen oxidoreductase (10-hydroxylating)
Reaction(IUBMB)
dihydrosanguinarine + NADPH + H+ + O2 = 10-hydroxydihydrosanguinarine + NADP+ + H2O [RN:R04702]
Reaction(KEGG)
Substrate
dihydrosanguinarine [CPD:C05191];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
10-hydroxydihydrosanguinarine [CPD:C05247];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450) involved in benzophenanthridine alkaloid synthesis in higher plants.
History
EC 1.14.13.56 created 1999
Pathway
Isoquinoline alkaloid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Reference
1
  Authors
De-Eknamkul, W., Tanahashi, T. and Zenk, M.H.
  Title
Enzymic 10-hydroxylation and 10-O-methylation of dihydrosanguinarine in dihydrochelirubine formation by Eschscholtzia.
  Journal
Phytochemistry 31 (1992) 2713-2717.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
144388-41-0

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