KEGG   ENZYME: 1.14.13.57Help
Entry
EC 1.14.13.57               Enzyme                                 

Name
dihydrochelirubine 12-monooxygenase;
dihydrochelirubine 12-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
dihydrochelirubine,NADPH:oxygen oxidoreductase (12-hydroxylating)
Reaction(IUBMB)
dihydrochelirubine + NADPH + H+ + O2 = 12-hydroxydihydrochelirubine + NADP+ + H2O [RN:R04708]
Reaction(KEGG)
Substrate
dihydrochelirubine [CPD:C05194];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
12-hydroxydihydrochelirubine [CPD:C05193];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450)
History
EC 1.14.13.57 created 1999
Pathway
Isoquinoline alkaloid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Reference
1
  Authors
Kammerer, L., De-Eknamkul, W. and Zenk, M.H.
  Title
Enzymic 12-hydroxylation and 12-O-methylation of dihydrochelirubine in dihydromacarpine formation by Thalictrum bulgaricum.
  Journal
Phytochemistry 36 (1994) 1409-1416.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
158736-41-5

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