KEGG   ENZYME: 1.14.13.62Help
Entry
EC 1.14.13.62               Enzyme                                 

Name
4-hydroxyquinoline 3-monooxygenase;
quinolin-4(1H)-one 3-monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
quinolin-4(1H)-one,NADH:oxygen oxidoreductase (3-oxygenating)
Reaction(IUBMB)
quinolin-4-ol + NADH + H+ + O2 = quinolin-3,4-diol + NAD+ + H2O [RN:R05154]
Reaction(KEGG)
Substrate
quinolin-4-ol [CPD:C06343];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
quinolin-3,4-diol;
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
Quinolin-4-ol exists largely as the quinolin-4(1H)-one tautomer.
History
EC 1.14.13.62 created 1999
Reference
1  [PMID:1627263]
  Authors
Block DW, Lingens F.
  Title
Microbial metabolism of quinoline and related compounds. XIII. Purification and properties of 1H-4-oxoquinoline monooxygenase from Pseudomonas putida strain 33/1.
  Journal
Biol. Chem. Hoppe. Seyler. 373 (1992) 249-54.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
144378-37-0

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