KEGG   ENZYME: 1.14.13.64Help
Entry
EC 1.14.13.64               Enzyme                                 

Name
4-hydroxybenzoate 1-hydroxylase;
4-hydroxybenzoate 1-monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)
Reaction(IUBMB)
4-hydroxybenzoate + NAD(P)H + 2 H+ + O2 = hydroquinone + NAD(P)+ + H2O + CO2 [RN:R01297 R01299]
Reaction(KEGG)
Substrate
4-hydroxybenzoate [CPD:C00156];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
hydroquinone [CPD:C00530];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001];
CO2 [CPD:C00011]
Comment
Requires FAD. The enzyme from Candida parapsilosis is specific for 4-hydroxybenzoate derivatives and prefers NADH to NADPH as electron donor.
History
EC 1.14.13.64 created 1999
Pathway
Benzoate degradation
Microbial metabolism in diverse environments
Reference
1  [PMID:7926672]
  Authors
van Berkel WJ, Eppink MH, Middelhoven WJ, Vervoort J, Rietjens IM.
  Title
Catabolism of 4-hydroxybenzoate in Candida parapsilosis proceeds through initial oxidative decarboxylation by a FAD-dependent 4-hydroxybenzoate 1-hydroxylase.
  Journal
FEMS. Microbiol. Lett. 121 (1994) 207-15.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
134214-78-1

DBGET integrated database retrieval system