KEGG   ENZYME: 1.14.13.66Help
Entry
EC 1.14.13.66               Enzyme                                 

Name
2-hydroxycyclohexanone 2-monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
2-hydroxycyclohexan-1-one,NADPH:oxygen 2-oxidoreductase (1,2-lactonizing)
Reaction(IUBMB)
2-hydroxycyclohexan-1-one + NADPH + H+ + O2 = 6-hydroxyhexan-6-olide + NADP+ + H2O [RN:R03281]
Reaction(KEGG)
Substrate
2-hydroxycyclohexan-1-one [CPD:C01147];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
6-hydroxyhexan-6-olide [CPD:C03241];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
The product decomposes spontaneously to 6-oxohexanoic acid (adipic semialdehyde).
History
EC 1.14.13.66 created 1978 as EC 1.14.12.6, transferred 1999 to EC 1.14.13.66
Pathway
Caprolactam degradation
Reference
1  [PMID:856571]
  Authors
Davey JF, Trudgill PW.
  Title
The metabolism of trans-cyclohexan-1,2-diol by an Acinetobacter species.
  Journal
Eur. J. Biochem. 74 (1977) 115-27.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
62628-31-3

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