KEGG   ENZYME: 1.14.13.73Help
Entry
EC 1.14.13.73               Enzyme                                 

Name
tabersonine 16-hydroxylase;
tabersonine-11-hydroxylase;
T11H
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
tabersonine,NADPH:oxygen oxidoreductase (16-hydroxylating)
Reaction(IUBMB)
tabersonine + NADPH + H+ + O2 = 16-hydroxytabersonine + NADP+ + H2O [RN:R05855]
Reaction(KEGG)
Substrate
tabersonine [CPD:C09244];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
16-hydroxytabersonine [CPD:C11643];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450).
History
EC 1.14.13.73 created 2002
Pathway
Indole alkaloid biosynthesis
Orthology
K12696  
tabersonine 16-hydroxylase
Reference
1  [PMID:12228585]
  Authors
St-Pierre B, De Luca V.
  Title
A Cytochrome P-450 Monooxygenase Catalyzes the First Step in the Conversion of Tabersonine to Vindoline in Catharanthus roseus.
  Journal
Plant. Physiol. 109 (1995) 131-139.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
250378-34-8

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