KEGG   ENZYME: 1.14.13.75Help
Entry
EC 1.14.13.75               Enzyme                                 

Name
vinorine hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
vinorine,NADPH:oxygen oxidoreductase (21alpha-hydroxylating)
Reaction(IUBMB)
vinorine + NADPH + H+ + O2 = vomilenine + NADP+ + H2O [RN:R05877]
Reaction(KEGG)
Substrate
vinorine [CPD:C11807];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
vomilenine [CPD:C01761];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450). Forms a stage in the biosynthesis of the indole alkaloid ajmaline.
History
EC 1.14.13.75 created 2002
Pathway
Indole alkaloid biosynthesis
Biosynthesis of secondary metabolites
Reference
1
  Authors
Falkenhagen, H. and Stockligt, J.
  Title
Enzymatic biosynthesis of vomilenine, a key intermediate of the ajmaline pathway, catalysed by a novel cytochrome P-450-dependent enzyme from plant cell cultures of Rauwolfia serpentina.
  Journal
Z. Naturforsch. C: Biosci. 50 (1995) 45-53.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
162875-03-8

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