KEGG   ENZYME: 1.14.13.85Help
Entry
EC 1.14.13.85               Enzyme                                 

Name
glyceollin synthase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
2-(or 4-)dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan,NADPH:oxygen oxidoreductase (cyclizing)
Reaction(IUBMB)
2-(or 4-)dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin + NADP+ + 2 H2O [RN:R07356 R07357]
Reaction(KEGG)
Substrate
2-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan [CPD:C15509];
4-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan [CPD:C15510];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
glyceollin [CPD:C01701];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450). Glyceollins II and III are formed from 2-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan whereas glyceollin I is formed from the 4-isomer.
History
EC 1.14.13.85 created 2004
Pathway
Isoflavonoid biosynthesis
Reference
1  [PMID:3369863]
  Authors
Welle R, Grisebach H.
  Title
Induction of phytoalexin synthesis in soybean: enzymatic cyclization of prenylated pterocarpans to glyceollin isomers.
  Journal
Arch. Biochem. Biophys. 263 (1988) 191-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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