KEGG   ENZYME: 1.14.13.87Help
Entry
EC 1.14.13.87               Enzyme                                 

Name
licodione synthase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
liquiritigenin,NADPH:oxygen oxidoreductase (licodione-forming)
Reaction(IUBMB)
liquiritigenin + NADPH + H+ + O2 = licodione + NADP+ + H2O [RN:R07198]
Reaction(KEGG)
Substrate
liquiritigenin [CPD:C09762];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
licodione [CPD:C01592];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450). It probably forms 2-hydroxyliquiritigenin which spontaneously forms licodione. NADH can act instead of NADPH, but more slowly.
History
EC 1.14.13.87 created 2004
Orthology
K13406  
licodione synthase
Reference
1  [PMID:12232298]
  Authors
Otani K, Takahashi T, Furuya T, Ayabe S.
  Title
Licodione Synthase, a Cytochrome P450 Monooxygenase Catalyzing 2-Hydroxylation of 5-Deoxyflavanone, in Cultured Glycyrrhiza echinata L. Cells.
  Journal
Plant. Physiol. 105 (1994) 1427-1432.
Reference
2  [PMID:9708921]
  Authors
Akashi T, Aoki T, Ayabe S.
  Title
Identification of a cytochrome P450 cDNA encoding (2S)-flavanone 2-hydroxylase of licorice (Glycyrrhiza echinata L.; Fabaceae) which represents licodione synthase and flavone synthase II.
  Journal
FEBS. Lett. 431 (1998) 287-90.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
157972-05-9

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