KEGG   ENZYME: 1.14.13.90Help
Entry
EC 1.14.13.90               Enzyme                                 

Name
zeaxanthin epoxidase;
Zea-epoxidase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
zeaxanthin,NAD(P)H:oxygen oxidoreductase
Reaction(IUBMB)
zeaxanthin + 2 NAD(P)H + 2 H+ + 2 O2 = violaxanthin + 2 NAD(P)+ + 2 H2O (overall reaction) [RN:R10070 R10071];
(1a) zeaxanthin + NAD(P)H + H+ + O2 = antheraxanthin + NAD(P)+ + H2O [RN:R06946 R07199];
(1b) antheraxanthin + NAD(P)H + H+ + O2 = violaxanthin + NAD(P)+ + H2O [RN:R06947 R07200]
Reaction(KEGG)
Substrate
zeaxanthin [CPD:C06098];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007];
antheraxanthin [CPD:C08579]
Product
violaxanthin [CPD:C08614];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001];
antheraxanthin [CPD:C08579]
Comment
A flavoprotein (FAD) that is active under conditions of low light. Along with EC 1.10.99.3, violaxanthin de-epoxidase, this enzyme forms part of the xanthophyll (or violaxanthin) cycle, which is involved in protecting the plant against damage by excess light. It will also epoxidize lutein in some higher-plant species.
History
EC 1.14.13.90 created 2005
Pathway
Carotenoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K09838  
zeaxanthin epoxidase
Genes
ATH: 
AT5G67030(ABA1)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj0g3v0062999.1(Lj0g3v0062999.1) Lj2g3v1874610.1(Lj2g3v1874610.1) Lj3g3v0463700.1(Lj3g3v0463700.1)
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
POPTR_0001s23620g POPTR_0005s18160g(POPTRDRAFT_760467) POPTR_0007s10980g(POPTRDRAFT_764537)
VVI: 
SLY: 
SPEN: 
SOT: 
SIND: 
BVG: 
NNU: 
OSA: 
4335984(OsABA2)
DOSA: 
Os04t0448900-00(Os04g0448900)
OBR: 
BDI: 
ZMA: 
100285076(GRMZM2G127139) 103641701(GRMZM5G848550) 103641704(GRMZM2G136344)
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
APRO: 
SMIN: 
v1.2.016478.t1(symbB.v1.2.016478.t1) v1.2.016479.t1(symbB.v1.2.016479.t1) v1.2.019826.t1(symbB.v1.2.019826.t1)
PTI: 
TPS: 
AAF: 
EHX: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:8521963]
  Authors
Buch K, Stransky H, Hager A.
  Title
FAD is a further essential cofactor of the NAD(P)H and O2-dependent zeaxanthin-epoxidase.
  Journal
FEBS. Lett. 376 (1995) 45-8.
Reference
2  [PMID:9624110]
  Authors
Bugos RC, Hieber AD, Yamamoto HY.
  Title
Xanthophyll cycle enzymes are members of the lipocalin family, the first identified from plants.
  Journal
J. Biol. Chem. 273 (1998) 15321-4.
Reference
3  [PMID:10890531]
  Authors
Thompson AJ, Jackson AC, Parker RA, Morpeth DR, Burbidge A, Taylor IB.
  Title
Abscisic acid biosynthesis in tomato: regulation of zeaxanthin epoxidase and 9-cis-epoxycarotenoid dioxygenase mRNAs by light/dark cycles, water stress and abscisic acid.
  Journal
Plant. Mol. Biol. 42 (2000) 833-45.
Reference
4  [PMID:11058750]
  Authors
Hieber AD, Bugos RC, Yamamoto HY.
  Title
Plant lipocalins: violaxanthin de-epoxidase and zeaxanthin epoxidase.
  Journal
Biochim. Biophys. Acta. 1482 (2000) 84-91.
Reference
5  [PMID:11506368]
  Authors
Frommolt R, Goss R, Wilhelm C.
  Title
The de-epoxidase and epoxidase reactions of Mantoniella squamata (Prasinophyceae) exhibit different substrate-specific reaction kinetics compared to spinach.
  Journal
Planta. 213 (2001) 446-56.
Reference
6  [PMID:11506368]
  Authors
Frommolt R, Goss R, Wilhelm C.
  Title
The de-epoxidase and epoxidase reactions of Mantoniella squamata (Prasinophyceae) exhibit different substrate-specific reaction kinetics compared to spinach.
  Journal
Planta. 213 (2001) 446-56.
Reference
7  [PMID:12844265]
  Authors
Matsubara S, Morosinotto T, Bassi R, Christian AL, Fischer-Schliebs E, Luttge U, Orthen B, Franco AC, Scarano FR, Forster B, Pogson BJ, Osmond CB.
  Title
Occurrence of the lutein-epoxide cycle in mistletoes of the Loranthaceae and Viscaceae.
  Journal
Planta. 217 (2003) 868-79.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
149718-34-3

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