KEGG   ENZYME: 1.14.13.91Help
Entry
EC 1.14.13.91               Enzyme                                 

Name
deoxysarpagine hydroxylase;
DOSH
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
10-deoxysarpagine,NADPH:oxygen oxidoreductase (10-hydroxylating)
Reaction(IUBMB)
10-deoxysarpagine + NADPH + H+ + O2 = sarpagine + NADP+ + H2O [RN:R05828]
Reaction(KEGG)
Substrate
10-deoxysarpagine [CPD:C11635];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
sarpagine [CPD:C09239];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450).
History
EC 1.14.13.91 created 2005
Pathway
Indole alkaloid biosynthesis
Biosynthesis of secondary metabolites
Reference
1  [PMID:12057637]
  Authors
Yu B, Ruppert M, Stockigt J.
  Title
Deoxysarpagine hydroxylase--a novel enzyme closing a short side pathway of alkaloid biosynthesis in Rauvolfia.
  Journal
Bioorg. Med. Chem. 10 (2002) 2479-83.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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