KEGG   ENZYME: 1.14.14.11Help
Entry
EC 1.14.14.11               Enzyme                                 

Name
styrene monooxygenase;
StyA;
SMO;
NSMOA
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
styrene,FADH2:oxygen oxidoreductase
Reaction(IUBMB)
styrene + FADH2 + O2 = (S)-2-phenyloxirane + FAD + H2O [RN:R05488]
Reaction(KEGG)
Substrate
styrene [CPD:C07083];
FADH2 [CPD:C01352];
O2 [CPD:C00007]
Product
(S)-2-phenyloxirane [CPD:C20782];
FAD [CPD:C00016];
H2O [CPD:C00001]
Comment
The enzyme catalyses the first step in the aerobic styrene degradation pathway. It forms a two-component system with a reductase (StyB) that utilizes NADH to reduce flavin-adenine dinucleotide, which is then transferred to the oxygenase.
History
EC 1.14.14.11 created 2011
Pathway
Styrene degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K14481  
styrene monooxygenase
Genes
PSV: 
Taxonomy
Reference
1  [PMID:15292130]
  Authors
Otto K, Hofstetter K, Rothlisberger M, Witholt B, Schmid A
  Title
Biochemical characterization of StyAB from Pseudomonas sp. strain VLB120 as a two-component flavin-diffusible monooxygenase.
  Journal
J. Bacteriol. 186 (2004) 5292-302.
  Sequence
Reference
2  [PMID:20675468]
  Authors
Tischler D, Kermer R, Groning JA, Kaschabek SR, van Berkel WJ, Schlomann M
  Title
StyA1 and StyA2B from Rhodococcus opacus 1CP: a multifunctional styrene monooxygenase system.
  Journal
J. Bacteriol. 192 (2010) 5220-7.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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