KEGG   ENZYME: 1.14.15.3Help
Entry
EC 1.14.15.3                Enzyme                                 
Name
alkane 1-monooxygenase;
alkane 1-hydroxylase;
omega-hydroxylase;
fatty acid omega-hydroxylase;
alkane monooxygenase;
1-hydroxylase;
alkane hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2;
With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
alkane,reduced-rubredoxin:oxygen 1-oxidoreductase
Reaction(IUBMB)
octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O [RN:R02879]
Reaction(KEGG)
Substrate
octane [CPD:C01387];
reduced rubredoxin [CPD:C00340];
O2 [CPD:C00007]
Product
1-octanol [CPD:C00756];
oxidized rubredoxin [CPD:C00435];
H2O [CPD:C00001]
Comment
Some enzymes in this group are heme-thiolate proteins (P-450). Also hydroxylates fatty acids in the omega-position.
Pathway
Fatty acid metabolism
Arachidonic acid metabolism
Retinol metabolism
Metabolic pathways
Orthology
K00496  
alkane 1-monooxygenase
K07425  
cytochrome P450, family 4, subfamily A
Genes
HSA: 
1579(CYP4A11) 284541(CYP4A22)
PTR: 
PPS: 
GGO: 
PON: 
MCC: 
MMU: 
100040843(Cyp4a32) 13117(Cyp4a10) 13118(Cyp4a12b) 13119(Cyp4a14) 230639(Cyp4a29-ps) 277753(Cyp4a12a) 435802(Cyp4a30b-ps) 666168(Cyp4a31)
RNO: 
24306(Cyp4a2) 266674(Cyp4a8) 298423(Cyp4a3) 50549(Cyp4a1)
CFA: 
475366(CYP4A38) 482506(CYP4A37) 610385(CYP4A11)
AML: 
FCA: 
101083281
BTA: 
511890(CYP4A11) 516085(CYP4A22)
SSC: 
100522145 403326(CYP4A24) 403327(CYP4A21)
ECB: 
100064020
MDO: 
100023663
SHR: 
100924766
OAA: 
100092213
ENL: 
A3UG_02310
SRR: 
SerAS9_1141
SRS: 
SerAS12_1141
SRA: 
SerAS13_1141
PSD: 
DSC_08960
PAE: 
PA1525(alkB2) PA2574(alkB1)
PAU: 
PA14_30810(alkB1) PA14_44700(alkB2)
PAP: 
PSPA7_2642 PSPA7_3808
PAG: 
PLES_27201(alkB1) PLES_38031(alkB2)
PAF: 
PAM18_2419(alkB1) PAM18_3523(alkB2)
PNC: 
NCGM2_2412(alkB2) NCGM2_3586(alkB1)
PDK: 
PADK2_12360 PADK2_18100
PSG: 
G655_12135 G655_17595
PFL: 
PFL_2935(alkB)
PFS: 
PFLU3535
PFC: 
PflA506_2496(alkB)
PPZ: 
H045_10220
PMY: 
Pmen_0443 Pmen_2750
PMK: 
MDS_1928
PDR: 
H681_15325
PRW: 
PsycPRwf_2053
ACI: 
ACIAD1411(alkM)
ACD: 
AOLE_10550 AOLE_13390
ACB: 
A1S_1641
ABM: 
ABSDF1860(alkM)
ABY: 
ABAYE2014(alkM)
ABC: 
ACICU_01666
ABN: 
AB57_1863
ABB: 
ABBFA_001858
ABX: 
ABK1_2124
ABZ: 
ABZJ_01827
ABR: 
ABTJ_02041
ABD: 
ABTW07_1882
ABH: 
M3Q_2018
ABAD: 
ABD1_16260(alkM)
ACC: 
BDGL_001009(alkM)
MAQ: 
Maqu_0440 Maqu_0610 Maqu_2843
MHC: 
MARHY2735(alkM) MARHY2847(alkB)
MAD: 
HP15_2574(alkB) HP15_2892(alkB)
MBS: 
MRBBS_1602(alkB1)
GNI: 
GNIT_1689
LPN: 
lpg2997
LPU: 
LPE509_00009
LPF: 
lpl2925
LPP: 
lpp3068
LPC: 
LPC_3312
LPA: 
lpa_04391
LPE: 
lp12_2989
LLO: 
LLO_2382
CYQ: 
Q91_1900 Q91_2194
HCH: 
HCH_04734(alkB)
ABO: 
ABO_0122(alkB2) ABO_2707(alkB1)
ADI: 
B5T_00103(alkB2) B5T_00721 B5T_04393
TOL: 
TOL_1175 TOL_1423 TOL_2658
SAGA: 
M5M_18065
GPB: 
HDN1F_04190(alkM)
RPI: 
Rpic_4109
RPF: 
Rpic12D_4221
BMA: 
BMA0635(alkB)
BMV: 
BMASAVP1_A2377(alkB)
BML: 
BMA10229_A2910(alkB)
BMN: 
BMA10247_1692(alkB)
BPS: 
BPSL2350
BPM: 
BURPS1710b_2801
BPL: 
BURPS1106A_2735(alkB)
BPD: 
BURPS668_2678(alkB)
BPR: 
GBP346_A2857
BPZ: 
BP1026B_I0975
BPQ: 
BPC006_I2776
BTE: 
BTH_I1814
BVI: 
Bcep1808_0897
BUR: 
Bcep18194_A4085 Bcep18194_B1222
BCN: 
Bcen_0501
BCH: 
Bcen2424_0980
BCM: 
Bcenmc03_0941
BCJ: 
BCAL3029
BAM: 
Bamb_0841
BAC: 
BamMC406_0853
BMU: 
Bmul_2418
BMJ: 
BMULJ_00816(alkB)
BCT: 
GEM_2246 GEM_2548
BXE: 
Bxe_B1208
BPY: 
Bphyt_5401
BGL: 
bglu_1g25240
BGD: 
bgla_1g28520
BUK: 
MYA_0870
ACK: 
C380_12125
MPT: 
Mpe_B0606(alkB)
BBA: 
Bd2197
BBAT: 
Bdt_2153
HDN: 
Hden_0732
RVA: 
Rvan_1309
CAK: 
Caul_5439
SIT: 
TM1040_2646
RSP: 
RSP_1467
RSH: 
Rsph17029_0118
RSQ: 
Rsph17025_0065
RSK: 
RSKD131_2858
RCP: 
RCAP_rcc02390
JAN: 
Jann_0394
PDE: 
Pden_2098
DSH: 
Dshi_0027(alkB1)
PSF: 
PSE_3490(alkB)
PGA: 
PGA1_c33550
PGL: 
PGA2_c31810
OAT: 
OAN307_c47130(alkB1)
OAR: 
OA238_c27230
NPP: 
PP1Y_AT31329
ACR: 
Acry_1262
AMV: 
ACMV_13020(alkB)
RCE: 
RC1_0393(alkB)
PBR: 
PB2503_09204
MTU: 
Rv3252c(alkB)
MTV: 
RVBD_3252c
MTC: 
MT3350(alkB)
MRA: 
MRA_3293(alkB)
MTF: 
TBFG_13281
MTB: 
TBMG_03300
MTK: 
TBSG_03323
MTZ: 
TBXG_003280
MTG: 
MRGA327_20020
MTE: 
CCDC5079_3000
MTL: 
CCDC5180_2963
MTO: 
MTCTRI2_3319(alkB)
MTD: 
UDA_3252c(alkB)
MTN: 
ERDMAN_3566(alkB)
MTJ: 
J112_17475
MTUB: 
MT7199_3294
MBO: 
Mb3280c(alkB)
MBB: 
BCG_3281c(alkB)
MBT: 
JTY_3277(alkB)
MBM: 
BCGMEX_3279c(alkB)
MBK: 
K60_033810
MAF: 
MAF_32630(alkB)
MCE: 
MCAN_32711(alkB)
MCQ: 
BN44_70036(alkB)
MCV: 
BN43_60261(alkB)
MCX: 
BN42_41302(alkB)
MCZ: 
BN45_60281(alkB)
MPA: 
MAP3364c
MAV: 
MAV_4215
MIT: 
OCO_40740
MIR: 
OCQ_42010
MIA: 
OCU_40650
MID: 
MIP_06136
MSM: 
MSMEG_1839
MSG: 
MSMEI_1797(alkB)
MSA: 
Mycsm_01384
MUL: 
MUL_2749(alkB_1)
MVA: 
Mvan_1742 Mvan_3100
MGI: 
Mflv_3369 Mflv_4721
MSP: 
Mspyr1_27000 Mspyr1_40540
MAB: 
MAB_3598c
MMV: 
MYCMA_1974(alkB)
MMC: 
Mmcs_1333
MKM: 
Mkms_1350
MJL: 
Mjls_1369
MJD: 
JDM601_2991(alkB)
MMI: 
MMAR_1291(alkB) MMAR_3516(alkB_1)
MRH: 
MycrhN_0412
MMM: 
W7S_20340
MCB: 
Mycch_1351 Mycch_2783
MLI: 
MULP_01451(alkB) MULP_03769(alkB_1)
ASD: 
AS9A_2113 AS9A_2121 AS9A_3799
CJK: 
jk1916(alkM)
CVA: 
CVAR_0139(alkB)
NFA: 
nfa46140 nfa46180
NCY: 
NOCYR_2725(alkB) NOCYR_2826(alkB) NOCYR_4341(alkA)
NBR: 
O3I_035145
RHA: 
RHA1_ro02534(alkB) RHA1_ro02535(rubA)
RER: 
RER_07460(alkB) RER_21620(alkB)
ROP: 
ROP_22570(alkB) ROP_pROB01-04350(alkB)
REQ: 
REQ_33430(alkB)
GBR: 
Gbro_4212
GOR: 
KTR9_2914
TPR: 
Tpau_2750
SRT: 
Srot_0768
NCA: 
Noca_0122
TCU: 
Tcur_0560
FRA: 
Francci3_1251
FRE: 
Franean1_2192
FRI: 
FraEuI1c_2181
FAL: 
FRAAL1986
AMD: 
AMED_6400
AMN: 
RAM_32810
AMM: 
AMES_6308
MAU: 
Micau_3940
MIL: 
ML5_4476
AMS: 
AMIS_28610
ASE: 
ACPL_4910(alkB)
CAI: 
Caci_1373
CWO: 
Cwoe_5739
TPX: 
Turpa_1759
HHY: 
Halhy_3303
BBD: 
Belba_3611
RSI: 
Runsl_1388
EOL: 
Emtol_2027
MTT: 
Ftrac_0880
FBC: 
FB2170_05910
NDO: 
DDD_1421
POM: 
MED152_06505
OHO: 
Oweho_0550
 » show all
Taxonomy
Reference
1  [PMID:4317878]
  Authors
Cardini G, Jurtshuk P.
  Title
The enzymatic hydroxylation of n-octane by Corynebacterium sp. strain 7E1C.
  Journal
J. Biol. Chem. 245 (1970) 2789-96.
  Organism
Corynebacterium sp.
Reference
2  [PMID:4395379]
  Authors
McKenna EJ, Coon MJ.
  Title
Enzymatic omega-oxidation. IV. Purification and properties of the omega-hydroxylase of Pseudomonas oleovorans.
  Journal
J. Biol. Chem. 245 (1970) 3882-9.
  Organism
Pseudomonas oleovorans
Reference
3  [PMID:4294330]
  Authors
Peterson JA, Kusunose M, Kusunose E, Coon MJ.
  Title
Enzymatic omega-oxidation. II. Function of rubredoxin as the electron carrier in omega-hydroxylation.
  Journal
J. Biol. Chem. 242 (1967) 4334-40.
  Organism
Pseudomonas oleovorans
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
9059-16-9
DBGET integrated database retrieval system